South Carolina Childcare Licensing
South Carolina Childcare Immunization Requirements (2026)
Children enrolled in a licensed South Carolina childcare center must show proof of age-appropriate immunization. South Carolina requires documentation for 9 vaccine series, with limited medical and legally permitted exemptions.
Licensing Agency
South Carolina Department of Social Services (DSS), Division of Early Care and Education — Child Care Licensing →Last updated: April 2026
Researched by the TotReady Research TeamSouth Carolina Immunization Requirements: The Specifics
South Carolina childcare licensing requires age-appropriate Current South Carolina Certificate of Immunization (DHEC Form 2740) required in each child's health record — S.C. Code Regs. 114-503.G.(6)(b) immunization for enrolled children (subject to documented medical or legally permitted exemptions).
South Carolina childcare licensing requires age-appropriate Hepatitis B immunization for enrolled children (subject to documented medical or legally permitted exemptions).
South Carolina childcare licensing requires age-appropriate Diphtheria, Tetanus, Pertussis (DTaP) immunization for enrolled children (subject to documented medical or legally permitted exemptions).
South Carolina childcare licensing requires age-appropriate Polio (IPV) immunization for enrolled children (subject to documented medical or legally permitted exemptions).
South Carolina childcare licensing requires age-appropriate Measles, Mumps, Rubella (MMR) immunization for enrolled children (subject to documented medical or legally permitted exemptions).
South Carolina childcare licensing requires age-appropriate Varicella (chickenpox) immunization for enrolled children (subject to documented medical or legally permitted exemptions).
South Carolina childcare licensing requires age-appropriate Hib (Haemophilus influenzae type b) — one dose at/after 15 months for children 15–59 months not yet age-appropriately complete; not required at age 5+ immunization for enrolled children (subject to documented medical or legally permitted exemptions).
South Carolina childcare licensing requires age-appropriate Pneumococcal Conjugate (PCV) — one dose on/after the 2nd birthday for children 24–59 months not yet age-appropriately complete immunization for enrolled children (subject to documented medical or legally permitted exemptions).
South Carolina childcare licensing requires age-appropriate Medical and religious exemptions documented on DHEC 2740 per SC DPH/DHEC immunization for enrolled children (subject to documented medical or legally permitted exemptions).
South Carolina Immunization Requirements Checklist
- Current South Carolina Certificate of Immunization (DHEC Form 2740) required in each child's health record — S.C. Code Regs. 114-503.G.(6)(b)
- Hepatitis B
- Diphtheria, Tetanus, Pertussis (DTaP)
- Polio (IPV)
- Measles, Mumps, Rubella (MMR)
- Varicella (chickenpox)
- Hib (Haemophilus influenzae type b) — one dose at/after 15 months for children 15–59 months not yet age-appropriately complete; not required at age 5+
- Pneumococcal Conjugate (PCV) — one dose on/after the 2nd birthday for children 24–59 months not yet age-appropriately complete
- Medical and religious exemptions documented on DHEC 2740 per SC DPH/DHEC
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South Carolina Immunization Requirements: Frequently Asked Questions
Which vaccines does South Carolina require for childcare enrollment?
South Carolina requires age-appropriate immunization records for: Current South Carolina Certificate of Immunization (DHEC Form 2740) required in each child's health record — S.C. Code Regs. 114-503.G.(6)(b), Hepatitis B, Diphtheria, Tetanus, Pertussis (DTaP), Polio (IPV), Measles, Mumps, Rubella (MMR), Varicella (chickenpox), Hib (Haemophilus influenzae type b) — one dose at/after 15 months for children 15–59 months not yet age-appropriately complete; not required at age 5+, Pneumococcal Conjugate (PCV) — one dose on/after the 2nd birthday for children 24–59 months not yet age-appropriately complete, Medical and religious exemptions documented on DHEC 2740 per SC DPH/DHEC.
Are immunization exemptions allowed in South Carolina?
South Carolina permits documented medical exemptions and, where state law allows, certain non-medical exemptions. Confirm the current exemption rules with the South Carolina Department of Social Services (DSS), Division of Early Care and Education — Child Care Licensing.
When must immunization records be on file in South Carolina?
South Carolina requires up-to-date immunization documentation at enrollment, with records kept current in each child's file thereafter.
South Carolina childcare licensing rules are amended regularly. This page is compiled from published South Carolina administrative codes and statutes for informational purposes only — always verify current requirements with the South Carolina Department of Social Services (DSS), Division of Early Care and Education — Child Care Licensing before relying on them. TotReady provides information and document templates, not legal or regulatory advice.